Natural inorganic gemstones are those that are created by geological processes and (usually) dug from the ground. They may or may not have been enhanced in some way - by dyeing, irradiation or heating for example - but the important consideration is that they have not been manufactured in any way. The complexities of the geochemical and geophysical processes that create gemstones means that larger stones are usually flawed in some way, even if such flaws are not visible to the naked eye or even under a loupe.
Synthetic inorganic gemstones are manufactured (man-made, lab-created, lab-grown etc.) but are chemically and optically identical to the natural form, and because the chemical processes can be controlled are usually flawless.
Simulated gemstones (known as simulants) look like the natural form but are chemically and/or optically different.
To complicate matters some natural gemstones can also be simulants, as can some synthetic gemstones.
So...
If you are buying synthetic gemstones make sure that you know their chemical composition before you buy. Ask the seller if the information is not voluntarily given. Gems described on certain websites as 'Lab-created emerald' have turned out to be spinel, cubic zirconium, corundum (in which case they should properly have been described as green sapphire) or even glass instead of being beryl coloured by chromium.
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